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Hormone-receptor interaction molecular aspects by

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Published by M. Dekker in New York .
Written in English

Subjects:

  • Hormones.,
  • Hormone receptors.

Book details:

Edition Notes

Includes bibliographical references and indexes.

Statementedited by Gerald S. Levey.
SeriesModern pharmacology-toxicology ;, v. 9
ContributionsLevey, Gerald S.
Classifications
LC ClassificationsQP571 .H657
The Physical Object
Paginationxii, 474 p. :
Number of Pages474
ID Numbers
Open LibraryOL4874175M
ISBN 100824764382
LC Control Number76000583

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With advances in molecular cell signaling methodologies, our understanding of hormone–receptor interactions was greatly advanced, and adrenergic receptors became the most extensively studied model system [9–15]: the basic concept that β-receptors mediate their effects through coupling to a stimulatory guanylyl nucleotide-binding protein (G protein or G s), stimulating adenylyl cyclase and. There is quantitation of hormone–receptor interaction by reliable radiotracer-binding techniques; detergent extraction of the insulin receptor with the retention of insulin binding; and purification of the insulin receptor to homogeneity by conventional and affinity chromatography methods. Vol number 1 FIBS January Review Letter HORMONE-RECEPTOR INTERACTIONS Ernst J. M. HELMREICH Department of Physiological Chemistry, University of Wurzburg, Wurzburg, GFR Received 3 November Hormone-receptor complexes are rather long lived allowing several discrete cycles of activation and deactivation of adenylate by: The interaction of a hormone with a receptor is characterized by the equilibrium dissociation constant (K d) of the ligand-receptor complex. K d values were determined by the dose-dependent.

Detailed description of modern methodological approaches for the analysis of the hormone-receptor interaction is presented. Concise and comprehensive theoretical bases for such investigations as. The hormone-receptor interaction triggers events at the cell; changing the concentration of the hormone, the number of receptors on the cell, or the affinity of the receptor for the hormone will all influence the magnitude of the effect. Hormones bring about their effects by modifying membrane transport, activating/suppressing genes to. Hormone receptor interactions (2/23) STUDY. Flashcards. Learn. Write. Spell. Test. PLAY. Match. Gravity. Created by. brockly day 1, after the intro. Terms in this set (29) hormon-receptor interaction has many characteristics (5) 1) highly specific: very low concernctration circulating (like 10^-6), and R must recognize out of vast others. Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 36) Abstract It has generally been assumed that there is a direct proportionality between the number of receptor sites filled (bound) by hormone and the magnitude of target-tissue by:

  Abstract. Thyroid hormone (TH) actions are mediated by nuclear receptors (TRs α and β) that bind triiodothyronine (T 3, 3,5,3′-triiodo-l-thyronine) with high affinity, and its precursor thyroxine (T 4, 3,5,3′,5′-tetraiodo-l-thyronine) with lower affinity.T 4 contains a bulky 5′ iodine group absent from T e T 3 is buried in the core of the ligand binding domain (LBD), we have. Hormone-receptor interactions--basic mechanisms. Smith RG. An understanding of the basic mechanisms of hormone action is becoming an important part of a clinician's training. With the advent of radioreceptor assays and their comparison with radioimmunoassays, we are becoming increasingly aware that the normal physiological function of a hormone Author: Smith Rg. Rodbard D. () Mathematics of Hormone-Receptor Interaction. In: O’Malley B.W., Means A.R. (eds) Receptors for Reproductive Hormones. Advances in Experimental Medicine and Biology, vol Cited by: Interaction of Steroid Hormone Receptors with the Transcription Initiation Complex Article Literature Review (PDF Available) in Endocrine Reviews 17(6) January with Reads.